{"id":1391,"date":"2021-01-20T13:15:32","date_gmt":"2021-01-20T12:15:32","guid":{"rendered":"https:\/\/blog.pamas.de\/messung-von-fetttropfchen-in-parenteraler-babynahrung\/"},"modified":"2021-01-21T14:04:04","modified_gmt":"2021-01-21T13:04:04","slug":"messung-von-fetttropfchen-in-parenteraler-babynahrung","status":"publish","type":"post","link":"https:\/\/blog.pamas.de\/en\/messung-von-fetttropfchen-in-parenteraler-babynahrung\/","title":{"rendered":"Lipid globule analysis in parenteral neonatal nutrition"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1391\" class=\"elementor elementor-1391 elementor-1382\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-49c673f elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default\" data-id=\"49c673f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7700005 ae-bg-gallery-type-default\" data-id=\"7700005\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-13c59be elementor-widget elementor-widget-text-editor\" data-id=\"13c59be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>With parenteral feeding, the alimentary tract is bypassed, and prepared nutrient solutions are injected directly into the vein. Doctors only prescribe this type of nutrient to seriously ill individuals when there is no other option. In the case of neonates, parenteral feeding is hypercritical but essential\u00a0for\u00a0survival.<\/p><p>The pharmaceutical faculty of the Federal University of Rio de Janeiro (<a href=\"https:\/\/ufrj.br\/en\/\"><em>Universidade Federal do Rio de Janeiro<\/em><\/a>) investigates in the field of parenteral nutrition. In a study, the research department intended to find out whether added trace elements and vitamins affect the physico-chemical stability of parenteral nutrient preparations for neonates. \u00a0The key parameter that is equated with the physico-chemical stability, is the size of lipid globules and their percentage content in the nutrient preparation. It is essential to know the size distribution of lipid globules in parenteral neonatal nutrition, as too large a fat globule may favour coalescence and the human body is unable to absorb them parenterally. An instable particle size distribution is potentially dangerous for the patient. \u00a0<\/p><p>The lipid globules of three different parenteral neonatal nutrient preparations were analysed. All three samples contained the basic ingredients with three differed in compositions. One contained vitamins, one trace elements and the third with both.<\/p><p>Up to now, there has not been any defined specific scientific standard for the analysis of lipid globules in parenteral neonatal nutrition. The research team of the University of Rio de Janeiro therefore referred to the existing pharmacopoeia USP 729 (<em>Globule Size Distribution in Lipid Injectable Emulsions<\/em>) and USP 788 (<em>Particulate Matter in Injections<\/em>). Both pharmacopoeias recommend the Light Extinction method for the analysis of injectables.<\/p><p>The laboratory particle counter, the <a href=\"https:\/\/www.pamas.de\/particle-counters\/products-by-name\/pamas-svss.html\">PAMAS SVSS<\/a>, was used for the Light Extinction method. A <a href=\"https:\/\/www.pamas.de\/sensors.html\">PAMAS HCB-LD-50\/50<\/a> light extinction sensor is integrated into the system. The <a href=\"https:\/\/www.pamas.de\/software\/pamas-usp.html\">PAMAS USP<\/a> software programme transfers the measuring results for data analysis.<\/p><p>According to USP 729, the percentage of fat residing in parenteral neonatal nutrition must not be larger than 0,05%. Or more precisely, the lipid injectable emulsion must not contain more than 0,05% of fat globules larger than 5 \u00b5m. Fat globules larger than 5 \u00b5m are of interest in pharmaceutical applications, since fat globules of this size can obstruct the lungs, causing pulmonary embolism or can be fatal, if they are ingested parenterally and in too high quantities.<\/p><p>Using the <a href=\"https:\/\/www.pamas.de\/particle-counters\/products-by-name\/pamas-svss.html\">PAMAS SVSS<\/a>, the scientists of the University of Rio de Janeiro were able to successfully, accurately and reliably find out that the stability of parenteral neonatal nutrition is not affected by additional vitamins and trace elements. Added vitamins and trace elements do not have a noticeable impact on the distribution of fat globules in injectable emulsions.<\/p><p><em>bibliography:<\/em><br \/><em>Bianca Lobo et al.: Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use. Nutrition Journal, 2012, 11:26.<\/em><\/p><p><em>photo: parenteral neonatal nutrition (Pixabay)<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>With parenteral feeding, the alimentary tract is bypassed, and prepared nutrient solutions are injected directly into the vein. Doctors only prescribe this type of nutrient to seriously ill individuals when there is no other option. In the case of neonates, parenteral feeding is hypercritical but essential\u00a0for\u00a0survival. The pharmaceutical faculty of the Federal University of Rio [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":1381,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[29],"tags":[143,145,146,144,147,142],"class_list":["post-1391","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-applications","tag-fettroepfchen-en","tag-lichtabschattungsprinzip-en","tag-liquid-globule-analysis","tag-pamas-svss-en","tag-parenteral-neonatal-nutrition","tag-parenterale-babynahrung-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lipid globule analysis in parenteral neonatal nutrition - PAMAS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.pamas.de\/en\/messung-von-fetttropfchen-in-parenteraler-babynahrung\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lipid globule analysis in parenteral neonatal nutrition - PAMAS\" \/>\n<meta property=\"og:description\" content=\"With parenteral feeding, the alimentary tract is bypassed, and prepared nutrient solutions are injected directly into the vein. Doctors only prescribe this type of nutrient to seriously ill individuals when there is no other option. In the case of neonates, parenteral feeding is hypercritical but essential\u00a0for\u00a0survival. The pharmaceutical faculty of the Federal University of Rio [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blog.pamas.de\/en\/messung-von-fetttropfchen-in-parenteraler-babynahrung\/\" \/>\n<meta property=\"og:site_name\" content=\"PAMAS\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-20T12:15:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-01-21T13:04:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blog.pamas.de\/wp-content\/uploads\/2021\/01\/Parenterale-Babynahrung.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"853\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Anja Mertens\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Anja Mertens\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blog.pamas.de\\\/en\\\/messung-von-fetttropfchen-in-parenteraler-babynahrung\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blog.pamas.de\\\/en\\\/messung-von-fetttropfchen-in-parenteraler-babynahrung\\\/\"},\"author\":{\"name\":\"Anja Mertens\",\"@id\":\"https:\\\/\\\/blog.pamas.de\\\/en\\\/#\\\/schema\\\/person\\\/cf07bebc7f5aa326dd6d912daf80dd07\"},\"headline\":\"Lipid globule analysis in parenteral neonatal nutrition\",\"datePublished\":\"2021-01-20T12:15:32+00:00\",\"dateModified\":\"2021-01-21T13:04:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blog.pamas.de\\\/en\\\/messung-von-fetttropfchen-in-parenteraler-babynahrung\\\/\"},\"wordCount\":474,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blog.pamas.de\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blog.pamas.de\\\/en\\\/messung-von-fetttropfchen-in-parenteraler-babynahrung\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blog.pamas.de\\\/wp-content\\\/uploads\\\/2021\\\/01\\\/Parenterale-Babynahrung.jpg\",\"keywords\":[\"Fettr\u00f6pfchen\",\"Lichtabschattungsprinzip\",\"liquid globule analysis\",\"PAMAS SVSS\",\"parenteral neonatal nutrition\",\"parenterale Babynahrung\"],\"articleSection\":[\"applications\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blog.pamas.de\\\/en\\\/messung-von-fetttropfchen-in-parenteraler-babynahrung\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blog.pamas.de\\\/en\\\/messung-von-fetttropfchen-in-parenteraler-babynahrung\\\/\",\"url\":\"https:\\\/\\\/blog.pamas.de\\\/en\\\/messung-von-fetttropfchen-in-parenteraler-babynahrung\\\/\",\"name\":\"Lipid globule analysis in parenteral neonatal nutrition - 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